Genotypic and Phenotypic Characteristics of Moraxella catarrhalis from Patients and Healthy Asymptomatic Participants among Preschool Children

Genotypic and Phenotypic Characteristics of Moraxella catarrhalis from Patients and Healthy Asymptomatic Participants among Preschool Children

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(1) Background: M.catarrhalis can ascend into the middle ear, where it is a prevalent causative agent of otitis media in children, or enter the lower respiratory tract, where it is associated with community-acquired pneumonia (CAP).In this study, we aimed to provide an overview of the prevalence of M.

catarrhalis in preschool children.(2) Methods: M.catarrhalis strains were isolated from samples.

All isolates were characterized in terms of serotypes (STs), virulence genes, multilocus sequence type, and antibiotic susceptibility.(3) Results: The percentages of 8 Piece Sectional with Chaise and Audio System strains expressing lipooligosaccharides (LOSs), serotype A, B, C, or unknown were 67.61%, 15.

71%, 4.28%, and 12.38%, respectively.

Among the strains, 185 (88.10%) carried ompB2, 207 (98.57%) carried ompE, and 151 ORG KIMCHI (71.

90%) carried ompCD.The most frequently identified STs were ST449 (n = 13), ST64 (n = 11), and ST215 (n = 10).The resistance rates to the antibiotics cefuroxime, azithromycin, and erythromycin were 43.

33%, 28.10%, and 39.05%, respectively.

(4) Conclusions: High prevalence of some-specific ST types and high rates of antibiotic resistance indicate the necessity for an increased vigilance of resistant strains, a rational use of antibiotics in preschool children, and most importantly, the surveillance of healthy asymptomatic participants preschool children with M.catarrhalis.Our findings provide a platform for the development of novel M.

catarrhalis vaccines.